Pharmaceutical Formulations Intermediates

Pharmaceutical Formulations Intermediates

Building R&D capabilities to create a Healthy product portfolio

Granules pioneered the concept of commercializing PFIs or Pre formulation Intermediates, with objective to reduce cost economics of products and to enable ease of operations for the manufacturer. PFIs enable “drum to hopper to compression/ encapsulation,” which offer cost and quality advantages on the supply chain, testing, technical and capital resources fronts at finished dosage manufacturers’ site. Not all molecules have properties that are amenable to be converted into PFIs. Hence, at the PFI R&D unit, we work on identifying and scaling up PFIs for molecules that have a sustainable market presence and focus on bringing in continuous cost efficiencies.

Benefits:

  • Reduces Vendor Development Cost- Customers save a significant amount on vendor development costs, since they need to deal with only one vendor for various materials and processes.
  • Simplifies Supply Chain Management- PFIs simplify supply chain complexities for customers and subsequently, their working capital costs also decline.
  • Lowers Testing Costs- Customers conduct a single test, resulting in significant savings. Our volume-based manufacturing and bigger batch size (six ton) ensure consistency in the quality of deliverables to the customers.
  • Reduces Capital Expenditure- Setting up a PFI facility comprises over 80% of the total investments in a normal oral solid dosage manufacturing facility. Our expertise to deliver PFI allows customers to stay asset light.
  • Provides Desired Release Properties- Customers enjoy access to PFIs that can be developed to provide release properties, similar to brand leaders. This makes it possible for Finished Dosage manufacturers to get favorable outcomes for their bioequivalence studies.
  • Develops Dry-bending with other APIs- We can design certain PFIs to be dry-blended with other APIs, without further granulation to obtain homogeneous mixtures. This helps make Finished Dosage forms in combination with other APIs.